Contribution
Basic concepts of acoustofluidic handling of aqueous particle suspensions
* Presenting author
Abstract:
The basic theoretical concepts of acoustofluidic handling of aqueous particle suspensions in lab-on-a-chip devices are presented. Especially the acoustic radiation force ["The acoustic radiation force on small particles ", H. Bruus, Lab Chip 12, 1014 (2012)], the acoustic body force ["Acoustic force density acting on inhomogeneous fluids in acoustic fields", J.T. Karlsen, P. Augustsson, and H. Bruus, Phys. Rev. Lett. 117, 114504 (2016)], and the Stokes drag from the acoustic streaming ["Acoustic streaming and its suppression in inhomogeneous fluids", J.T. Karlsen, W. Qiu, P. Augustsson, and H. Bruus, Phys. Rev. Lett. 120, 054501 (2018)] is discussed with emphasis on the cross-over in particle dynamics from being dominated by the radiation force for particles larger than 2 um (cells) to being dominated by the streaming-induced drag force for particles smaller than 2 um (bacteria and extra cellular vesicles) ["A numerical study of microparticle acoustophoresis driven by acoustic radiation forces and streaming-induced drag forces", P.B. Muller, R. Barnkob, M.J.H. Jensen, and H. Bruus Lab Chip 12, 4617 (2012)]. The concepts are exemplified by numerical simulations, which provide a starting point for the following talks on applications of acoustofluidics in the formation of 3D cell cultures, in cancer therapy, and in medical diagnostics.